Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
AssigneeBaylor Research Institute
InventorsAjay Goel, Keun Hur, Yuji Toiyama, C. Richard Boland
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Abstract
Methods and compositions for the diagnosis, prognosis and classification of cancer, especially colorectal cancer, are provided. For example, in certain aspects methods for cancer prognosis using expression or methylation analysis of selected biomarkers are described. Particular aspects of the present invention may include methods and biomarkers for diagnosing or detecting colorectal cancer or metastasis in a subject by measuring a level of expression of biomarker miRNA such as miR-885-5p in the sample from the subject and evaluating the risk of developing cancer or metastasis in the subject.
Claims9
A method for treating colorectal cancer in a subject suspected of having or determined to have a colorectal cancer, comprising:
- treating the subject with an adjuvant therapy comprising a chemotherapeutic agent;
- wherein the subject was determined to have increased expression level of miR-885-5p and increased expression level of one or more of miR-21, miR-200c, and miR-203 in a serum sample from the subject compared to a control or reference level of expression.
Dependencies are inferred from the claim text.