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US 9,868,961 B2Granted
Methods and compositions for localized secretion of anti-CTLA-4 antibodies
AssigneeThe Regents of the University of California
InventorsJames Allison, Michael Curran
Life of this patent
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Abstract
The present invention provides compositions and methods for effectuating the localized expression of anti-CTLA-4 antibody proximal to a target tissue in a patient.
Claims14
A viral vector comprising a nucleic acid encoding an anti-CTLA-4 antibody that binds to the extracellular domain of CTLA-4 and inhibits CTLA-4 signaling;
- wherein said antibody comprises all or part of an Fc region;
- and wherein said antibody comprises a variant hinge region lacking a cysteine residue capable of forming a disulphide linkage and exhibits reduced effector function.
Dependencies are inferred from the claim text.