Placental like alkaline phosphatase (PLAP) promoter mediated cell targeting
AssigneesNational Brain Research Centre, All India Institute of Medical Sciences
InventorsSubrata Sinha, Imran Khan, Mohammad Khalid Zakaria, Kunzang Chosdol, Parthaprasad Chattopadhyay
Life of this patent
Estimating the term…
Abstract
The present invention relates to cell specific therapeutic modality by using a region of the PLAP Promoter. The invention further relates to specific expression of therapeutically PLAP useful sequences for specific transcriptional activation of this gene. The invention also relates to the PLAP region which may be used alone or in combination with other regions like enhancer sequences that augment cell or tumour specific gene expression.
Claims11
A nucleic acid fusion construct consisting of SEQ ID NO:
- 1 and a tumor specific enhancer response element, wherein the tumor specific enhancer response element is selected from the group consisting of NFκB enhancer, Hypoxia inducible factor (HIF), and prostate specific antigen enhancer.
A nucleic acid fusion construct comprising SEQ ID NO:
- 1 and multiple repeats of the tumor specific enhancer response element wherein the tumor specific enhancer response element is selected from the group consisting of NFκB enhancer, Hypoxia inducible factor (HIF), prostate specific antigen enhancer, or artificial enhancers.
A nucleic acid fusion construct comprising SEQ ID NO:
- 1 and a tumor specific enhancer response element, wherein the tumor specific enhancer response element is NFκB enhancer response element.
Dependencies are inferred from the claim text.