Compositions and methods for “resistance-proof” SiRNA therapeutics for influenza

A pharmaceutical composition comprising at least two different siRNA molecules and a pharmaceutically acceptable polymeric carrier, wherein one of the at least two different siRNA molecules targets a conserved region of an influenza A virus gene and is selected from the group consisting of molecules 89 (SEQ ID NOS 14 and 11) and 91 (SEQ ID NOS 61 and 68) as shown in Table 5 and the other of the at least two different siRNA molecules targets a conserved region of a different influenza A virus gene and is selected from the group consisting of molecules 93 (SEQ ID NOS 62 and 69), 95 (SEQ ID NOS 63 and 70), 97 (SEQ ID NOS 64 and 71), 99 (SEQ ID NOS 65 and 72), 101 (SEQ ID NOS 66 and 73), 103 (SEQ ID NOS 12 and 13), and 105 (SEQ ID NOS 67 and 74) as shown in Table 5.