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US 9,868,790 B2Granted
Synergistic combinations of OX40L antibodies for the treatment of GvHD
AssigneeKymab Limited
InventorsPhilip Bland-Ward, Miha Kosmac, Steve Holmes, Ian Kirby, Jamie Campbell
Life of this patent
Estimating the term…
Abstract
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
Claims29
A method of treating or preventing graft versus host disease (GvHD) in a human subject in need thereof, comprising administering to the subject a therapeutically or prophylactically effective amount of:
- a. at least one anti-OX40L antibody or fragment thereof that antagonizes specific binding of OX40 to OX40L;
- and
- b. at least one mTOR inhibitor.
A method of treating or preventing transplant rejection in a human subject in need thereof, comprising administering to the subject a therapeutically or prophylactically effective amount of:
- a. at least one anti-OX40L antibody or fragment thereof that antagonizes specific binding of OX40 to OX40L;
- and
- b. at least one mTOR inhibitor.
Dependencies are inferred from the claim text.