Antibodies against human and canine IL-13RA2
AssigneeWake Forest University Health Sciences
InventorsWaldemar Debinski, Denise Mazess Herpai
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Abstract
Provided herein is an antibody (e.g., an isolated antibody) that specifically binds an epitope (e.g., linear epitope) within amino acids spanning the extracellular portion of human IL-13RA2. In some embodiments, the amino acids spanning the extracellular portion of human IL-13RA2 have at least 90% identity with the corresponding canine sequence of IL-13RA2. In some embodiments, the antibody specifically binds both human and canine IL-13RA2. In some embodiments, the antibody is a monoclonal antibody. In some embodiments, the antibody is a recombinant antibody. In some embodiments, the antibody is humanized. In some embodiments, the antibody is the monoclonal antibody produced by hybridoma 1E10B9 or a recombinant form thereof.
Claims14
An antibody that specifically binds an epitope within amino acids spanning the extracellular portion of human IL-13RA2, wherein said antibody specifically binds to both human and canine IL-13RA2;
- and
- (i) wherein said epitope is within amino acids of SEQ ID NO:1 (Peptide 1);
- SEQ ID NO:2 (Peptide 2);
- or SEQ ID NO:3 (Peptide 3), or
- (ii) wherein said epitope comprises at least 4 consecutive amino acids from SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3.
Dependencies are inferred from the claim text.