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US 9,868,783 B2Granted
Inhibition of the synthesis of beta-app or the activity of the A-β peptide in the choroid plexus
AssigneesCentre National De La Recherche Scientifique, College De France, Institut National de la Sante et de la Recherche Medicale
InventorsAriel Di Nardo, Kenneth Lee Moya, Karen Arnaud, Alain Prochiantz
Life of this patent
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Abstract
The invention relates to the treatment of neurodegenerative diseases, in particular Alzheimer's disease, by inhibition of the synthesis of βAPP or of the activity of the Aβ peptide in the choroid plexus.
Claims9
A method of decreasing the synthesis of βAPP in the choroid plexus of a patient affected with Alzheimer's disease, comprising administering an expression vector coding for an inhibitor of the βAPP protein to said patient targeting the choroid plexuses of said patient,
- said inhibitor being selected from antisense oligonucleotides and interfering RNAs directed against the gene coding of said βAPP protein, and
- said vector being derived from an adeno-associated virus allowing specific expression of said inhibitor in choroid plexus cells, and/or
- said inhibitor being under control of a specific promoter of cells of the choroid plexus.
Dependencies are inferred from the claim text.