DRG11-responsive (DRAGON) gene family
AssigneeThe General Hospital Corporation
InventorsClifford J. Woolf, Tarek A. Samad
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Abstract
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.
Claims6
A pharmaceutical composition comprising a vector derived from a plasmid or bacteriophage comprising a promoter operably linked to an antisense nucleic acid molecule, and a pharmaceutically acceptable carrier, wherein the antisense nucleic acid molecule is at least 40 nucleotides in length and hybridizes under high stringency conditions to any complementary portion of a coding region of a nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 1, 2, 3, 4, 31, 32, 25, 26 and 27, wherein the complementary portion of the coding region is the length of the antisense nucleic acid molecule, wherein the vector directs expression of the antisense nucleic acid molecule, and wherein the complementary portion of the coding region of the nucleic acid sequence selected from the group consisting of SEQ ID NOs:
- 1, 2, 3, 4, 31, 32, 25, 26, and 27 encodes a portion of an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 5, 6, 7, 8, 9, 10, 28, 29, and 30, respectively.
Dependencies are inferred from the claim text.