US 9,868,777 B2Granted

CMV neutralizing antigen binding proteins

AssigneesMerck Sharp & Dohme Corp., Board of Regents, The University of Texas System

InventorsTong-Ming Fu, Dai Wang, Zhiqiang An

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Abstract

The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). Also encompassed by the invention are antigen binding proteins that have been humanized. The antigen binding proteins of the invention are useful as a therapeutic agent for treating and/or preventing CMV infections in a patient in need thereof.

Claims10

Dependent claims

A recombinant antigen binding protein comprising a heavy chain variable region comprising a CDR1, CDR2 and CDR3 selected from the group consisting of:

(h-a) a CDR1 comprising SEQ ID NO:136, a CDR2 comprising SEQ ID NO:137 and a CDR3 comprising SEQ ID NO:138;
(h-b) a CDR1 comprising SEQ ID NO:139, a CDR2 comprising SEQ ID NO:140 and a CDR3 comprising SEQ ID NO:141;
(h-c) a CDR1 comprising SEQ ID NO:142, a CDR2 comprising SEQ ID NO:143 and a CDR3 comprising SEQ ID NO:144;
(h-d) a CDR1 comprising SEQ ID NO:145, a CDR2 comprising SEQ ID NO:146 and a CDR3 comprising SEQ ID NO:147;
(h-e) a CDR1 comprising SEQ ID NO:148, a CDR2 comprising SEQ ID NO:149 and a CDR3 comprising SEQ ID NO:150;
(h-f) a CDR1 comprising SEQ ID NO:151, a CDR2 comprising SEQ ID NO:152 and a CDR3 comprising SEQ ID NO:153;
(h-g) a CDR1 comprising SEQ ID NO:154, a CDR2 comprising SEQ ID NO:155 and a CDR3 comprising SEQ ID NO:156;
(h-h) a CDR1 comprising SEQ ID NO:157, a CDR2 comprising SEQ ID NO:158 and a CDR3 comprising SEQ ID NO:159;
(h-i) a CDR1 comprising SEQ ID NO:160, a CDR2 comprising SEQ ID NO:161 and a CDR3 comprising SEQ ID NO:162;
(h-j) a CDR1 comprising SEQ ID NO:163, a CDR2 comprising SEQ ID NO:164 and a CDR3 comprising SEQ ID NO:165;
(h-k) a CDR1 comprising SEQ ID NO:166, a CDR2 comprising SEQ ID NO:167 and a CDR3 comprising SEQ ID NO:168;
(h-l) a CDR1 comprising SEQ ID NO:169, a CDR2 comprising SEQ ID NO:170 and a CDR3 comprising SEQ ID NO:171;
(h-m) a CDR1 comprising SEQ ID NO:172, a CDR2 comprising SEQ ID NO:173 and a CDR3 comprising SEQ ID NO:174;
(h-n) a CDR1 comprising SEQ ID NO:175, a CDR2 comprising SEQ ID NO:176 and a CDR3 comprising SEQ ID NO:177;
(h-o) a CDR1 comprising SEQ ID NO:178, a CDR2 comprising SEQ ID NO:179 and a CDR3 comprising SEQ ID NO:180;
(h-p) a CDR1 comprising SEQ ID NO:181, a CDR2 comprising SEQ ID NO:182 and a CDR3 comprising SEQ ID NO:183;
(h-q) a CDR1 comprising SEQ ID NO:184, a CDR2 comprising SEQ ID NO:185 and a CDR3 comprising SEQ ID NO:186;
(h-r) a CDR1 comprising SEQ ID NO:187, a CDR2 comprising SEQ ID NO:188 and a CDR3 comprising SEQ ID NO:189;
(h-s) a CDR1 comprising SEQ ID NO:190, a CDR2 comprising SEQ ID NO:191 and a CDR3 comprising SEQ ID NO:192;
(h-t) a CDR1 comprising SEQ ID NO:193, a CDR2 comprising SEQ ID NO:194 and a CDR3 comprising SEQ ID NO:195;
(h-u) a CDR1 comprising SEQ ID NO:196, a CDR2 comprising SEQ ID NO:197 and a CDR3 comprising SEQ ID NO:198;
(h-v) a CDR1 comprising SEQ ID NO:199, a CDR2 comprising SEQ ID NO:200 and a CDR3 comprising SEQ ID NO:201;
(h-w) a CDR1 comprising SEQ ID NO:202, a CDR2 comprising SEQ ID NO:203 and a CDR3 comprising SEQ ID NO:204;
(h-x) a CDR1 comprising SEQ ID NO:205, a CDR2 comprising SEQ ID NO:206 and a CDR3 comprising SEQ ID NO:207;
(h-y) a CDR1 comprising SEQ ID NO:208, a CDR2 comprising SEQ ID NO:209 and a CDR3 comprising SEQ ID NO:210;
(h-z) a CDR1 comprising SEQ ID NO:211, a CDR2 comprising SEQ ID NO:212 and a CDR3 comprising SEQ ID NO:213;
(h-a′) a CDR1 comprising SEQ ID NO:214, a CDR2 comprising SEQ ID NO:215 and a CDR3 comprising SEQ ID NO:216;
(h-b′) a CDR1 comprising SEQ ID NO:217, a CDR2 comprising SEQ ID NO:218 and a CDR3 comprising SEQ ID NO:219;
(h-c′) a CDR1 comprising SEQ ID NO:220, a CDR2 comprising SEQ ID NO:221 and a CDR3 comprising SEQ ID NO:222;
(h-d′) a CDR1 comprising SEQ ID NO:223, a CDR2 comprising SEQ ID NO:224 and a CDR3 comprising SEQ ID NO:225;
(h-e′) a CDR1 comprising SEQ ID NO:226, a CDR2 comprising SEQ ID NO:227 and a CDR3 comprising SEQ ID NO:228;
(h-f′) a CDR1 comprising SEQ ID NO:229, a CDR2 comprising SEQ ID NO:230 and a CDR3 comprising SEQ ID NO:231;
(h-g′) a CDR1 comprising SEQ ID NO:232, a CDR2 comprising SEQ ID NO:233 and a CDR3 comprising SEQ ID NO:234;
(h-h′) a CDR1 comprising SEQ ID NO:235, a CDR2 comprising SEQ ID NO:236 and a CDR3 comprising SEQ ID NO:237;
(h-i′) a CDR1 comprising SEQ ID NO:238, a CDR2 comprising SEQ ID NO:239 and a CDR3 comprising SEQ ID NO:240;
(h-j′) a CDR1 comprising SEQ ID NO:241, a CDR2 comprising SEQ ID NO:242 and a CDR3 comprising SEQ ID NO:243;
(h-k′) a CDR1 comprising SEQ ID NO:244, a CDR2 comprising SEQ ID NO:245 and a CDR3 comprising SEQ ID NO:246;
(h-l′) a CDR1 comprising SEQ ID NO:247, a CDR2 comprising SEQ ID NO:248 and a CDR3 comprising SEQ ID NO:249;
(h-m′) a CDR1 comprising SEQ ID NO:250, a CDR2 comprising SEQ ID NO:251 and a CDR3 comprising SEQ ID NO:252;
(h-n′) a CDR1 comprising SEQ ID NO:253, a CDR2 comprising SEQ ID NO:254 and a CDR3 comprising SEQ ID NO:255;
(h-o′) a CDR1 comprising SEQ ID NO:256, a CDR2 comprising SEQ ID NO:257 and a CDR3 comprising SEQ ID NO:258;
(h-p′) a CDR1 comprising SEQ ID NO:259, a CDR2 comprising SEQ ID NO:260 and a CDR3 comprising SEQ ID NO:261;
(h-q′) a CDR1 comprising SEQ ID NO:262, a CDR2 comprising SEQ ID NO:263 and a CDR3 comprising SEQ ID NO:264;
(h-r′) a CDR1 comprising SEQ ID NO:265, a CDR2 comprising SEQ ID NO:266 and a CDR3 comprising SEQ ID NO:267;
and
(h-s′) a CDR1 comprising SEQ ID NO:268, a CDR2 comprising SEQ ID NO:269 and a CDR3 comprising SEQ ID NO:270;
wherein the antigen binding protein specifically binds to CMV.

44 more elements

A recombinant antigen binding protein comprising a light chain variable region and a heavy chain variable region selected from the group consisting of:

(a) a light chain variable region comprising a complementarity determining region (CDR) 1 comprising SEQ ID NO:1, a CDR2 comprising SEQ ID NO:2 and a CDR3 comprising SEQ ID NO:3 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:136, a CDR2 comprising SEQ ID NO:137 and a CDR3 comprising SEQ ID NO:138;
(b) a light chain variable region comprising a CDR1 comprising SEQ ID NO:4, a CDR2 comprising SEQ ID NO:5 and a CDR3 comprising SEQ ID NO:6 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:139, a CDR2 comprising SEQ ID NO:140 and a CDR3 comprising SEQ ID NO:141;
(c) a light chain variable region comprising a CDR1 comprising SEQ ID NO:7, a CDR2 comprising SEQ ID NO:8 and a CDR3 comprising SEQ ID NO:9 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:142, a CDR2 comprising SEQ ID NO:143 and a CDR3 comprising SEQ ID NO:144;
(d) a light chain variable region comprising a CDR1 comprising SEQ ID NO:10, a CDR2 comprising SEQ ID NO:11 and a CDR3 comprising SEQ ID NO:12 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:145, a CDR2 comprising SEQ ID NO:146 and a CDR3 comprising SEQ ID NO:147;
(e) a light chain variable region comprising a CDR1 comprising SEQ ID NO:13, a CDR2 comprising SEQ ID NO:14 and a CDR3 comprising SEQ ID NO:15 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:148, a CDR2 comprising SEQ ID NO:149 and a CDR3 comprising SEQ ID NO:150;
(f) a light chain variable region comprising a CDR1 comprising SEQ ID NO:16, a CDR2 comprising SEQ ID NO:17 and a CDR3 comprising SEQ ID NO:18 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:151, a CDR2 comprising SEQ ID NO:152 and a CDR3 comprising SEQ ID NO:153;
(g) a light chain variable region comprising a CDR1 comprising SEQ ID NO:19, a CDR2 comprising SEQ ID NO:20 and a CDR3 comprising SEQ ID NO:21 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:154, a CDR2 comprising SEQ ID NO:155 and a CDR3 comprising SEQ ID NO:156;
(h) a light chain variable region comprising a CDR1 comprising SEQ ID NO:22, a CDR2 comprising SEQ ID NO:23 and a CDR3 comprising SEQ ID NO:24 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:157, a CDR2 comprising SEQ ID NO:158 and a CDR3 comprising SEQ ID NO:159;
(i) a light chain variable region comprising a CDR1 comprising SEQ ID NO:25, a CDR2 comprising SEQ ID NO:26 and a CDR3 comprising SEQ ID NO:27 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:160, a CDR2 comprising SEQ ID NO:161 and a CDR3 comprising SEQ ID NO:162;
(j) a light chain variable region comprising a CDR1 comprising SEQ ID NO:28, a CDR2 comprising SEQ ID NO:29 and a CDR3 comprising SEQ ID NO:30 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:163, a CDR2 comprising SEQ ID NO:164 and a CDR3 comprising SEQ ID NO:165;
(k) a light chain variable region comprising a CDR1 comprising SEQ ID NO:31, a CDR2 comprising SEQ ID NO:32 and a CDR3 comprising SEQ ID NO:33 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:166, a CDR2 comprising SEQ ID NO:167 and a CDR3 comprising SEQ ID NO:168;
(l) a light chain variable region comprising a CDR1 comprising SEQ ID NO:34, a CDR2 comprising SEQ ID NO:35 and a CDR3 comprising SEQ ID NO:36 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:169, a CDR2 comprising SEQ ID NO:170 and a CDR3 comprising SEQ ID NO:171;
(m) a light chain variable region comprising a CDR1 comprising SEQ ID NO:37, a CDR2 comprising SEQ ID NO:38 and a CDR3 comprising SEQ ID NO:39 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:172, a CDR2 comprising SEQ ID NO:173 and a CDR3 comprising SEQ ID NO:174;
(n) a light chain variable region comprising a CDR1 comprising SEQ ID NO:40, a CDR2 comprising SEQ ID NO:41 and a CDR3 comprising SEQ ID NO:42 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:175, a CDR2 comprising SEQ ID NO:176 and a CDR3 comprising SEQ ID NO:177;
(o) a light chain variable region comprising a CDR1 comprising SEQ ID NO:43, a CDR2 comprising SEQ ID NO:44 and a CDR3 comprising SEQ ID NO:45 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:178, a CDR2 comprising SEQ ID NO:179 and a CDR3 comprising SEQ ID NO:180;
(p) a light chain variable region comprising a CDR1 comprising SEQ ID NO:46, a CDR2 comprising SEQ ID NO:47 and a CDR3 comprising SEQ ID NO:48 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:181, a CDR2 comprising SEQ ID NO:182 and a CDR3 comprising SEQ ID NO:183;
(q) a light chain variable region comprising a CDR1 comprising SEQ ID NO:49, a CDR2 comprising SEQ ID NO:50 and a CDR3 comprising SEQ ID NO:51 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:184, a CDR2 comprising SEQ ID NO:185 and a CDR3 comprising SEQ ID NO:186;
(r) a light chain variable region comprising a CDR1 comprising SEQ ID NO:52, a CDR2 comprising SEQ ID NO:53 and a CDR3 comprising SEQ ID NO:54 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:187, a CDR2 comprising SEQ ID NO:188 and a CDR3 comprising SEQ ID NO:189;
(s) a light chain variable region comprising a CDR1 comprising SEQ ID NO:55, a CDR2 comprising SEQ ID NO:56 and a CDR3 comprising SEQ ID NO:57 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:190, a CDR2 comprising SEQ ID NO:191 and a CDR3 comprising SEQ ID NO:192;
(t) a light chain variable region comprising a CDR1 comprising SEQ ID NO:58, a CDR2 comprising SEQ ID NO:59 and a CDR3 comprising SEQ ID NO:60 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:193, a CDR2 comprising SEQ ID NO:194 and a CDR3 comprising SEQ ID NO:195;
(u) a light chain variable region comprising a CDR1 comprising SEQ ID NO:61, a CDR2 comprising SEQ ID NO:62 and a CDR3 comprising SEQ ID NO:63 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:196, a CDR2 comprising SEQ ID NO:197 and a CDR3 comprising SEQ ID NO:198;
(v) a light chain variable region comprising a CDR1 comprising SEQ ID NO:64, a CDR2 comprising SEQ ID NO:65 and a CDR3 comprising SEQ ID NO:66 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:199, a CDR2 comprising SEQ ID NO:200 and a CDR3 comprising SEQ ID NO:201;
(w) a light chain variable region comprising a CDR1 comprising SEQ ID NO:67, a CDR2 comprising SEQ ID NO:68 and a CDR3 comprising SEQ ID NO:69 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:202, a CDR2 comprising SEQ ID NO:203 and a CDR3 comprising SEQ ID NO:204;
(x) a light chain variable region comprising a CDR1 comprising SEQ ID NO:70, a CDR2 comprising SEQ ID NO:71 and a CDR3 comprising SEQ ID NO:72 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:205, a CDR2 comprising SEQ ID NO:206 and a CDR3 comprising SEQ ID NO:207;
(y) a light chain variable region comprising a CDR1 comprising SEQ ID NO:73, a CDR2 comprising SEQ ID NO:74 and a CDR3 comprising SEQ ID NO:75 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:208, a CDR2 comprising SEQ ID NO:209 and a CDR3 comprising SEQ ID NO:210;
(z) a light chain variable region comprising a CDR1 comprising SEQ ID NO:76, a CDR2 comprising SEQ ID NO:77 and a CDR3 comprising SEQ ID NO:78 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:211, a CDR2 comprising SEQ ID NO:212 and a CDR3 comprising SEQ ID NO:213;
(a′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:79, a CDR2 comprising SEQ ID NO:80 and a CDR3 comprising SEQ ID NO:81 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:214, a CDR2 comprising SEQ ID NO:215 and a CDR3 comprising SEQ ID NO:216;
(b′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:82, a CDR2 comprising SEQ ID NO:83 and a CDR3 comprising SEQ ID NO:84 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:217, a CDR2 comprising SEQ ID NO:218 and a CDR3 comprising SEQ ID NO:219;
(c′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:85, a CDR2 comprising SEQ ID NO:86 and a CDR3 comprising SEQ ID NO:87 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:220, a CDR2 comprising SEQ ID NO:221 and a CDR3 comprising SEQ ID NO:222;
(d′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:88, a CDR2 comprising SEQ ID NO:89 and a CDR3 comprising SEQ ID NO:90 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:223, a CDR2 comprising SEQ ID NO:224 and a CDR3 comprising SEQ ID NO:225;
(e′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:91, a CDR2 comprising SEQ ID NO:92 and a CDR3 comprising SEQ ID NO:93 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:226, a CDR2 comprising SEQ ID NO:227 and a CDR3 comprising SEQ ID NO:228;
(f′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:94, a CDR2 comprising SEQ ID NO:95 and a CDR3 comprising SEQ ID NO:96 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:229, a CDR2 comprising SEQ ID NO:230 and a CDR3 comprising SEQ ID NO:231;
(g′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:97, a CDR2 comprising SEQ ID NO:98 and a CDR3 comprising SEQ ID NO:99 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:232, a CDR2 comprising SEQ ID NO:233 and a CDR3 comprising SEQ ID NO:234;
(h′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:100, a CDR2 comprising SEQ ID NO:101 and a CDR3 comprising SEQ ID NO:102 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:235, a CDR2 comprising SEQ ID NO:236 and a CDR3 comprising SEQ ID NO:237;
(i′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:103, a CDR2 comprising SEQ ID NO:104 and a CDR3 comprising SEQ ID NO:105 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:238, a CDR2 comprising SEQ ID NO:239 and a CDR3 comprising SEQ ID NO:240;
(j′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:106, a CDR2 comprising SEQ ID NO:107 and a CDR3 comprising SEQ ID NO:108 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:241, a CDR2 comprising SEQ ID NO:242 and a CDR3 comprising SEQ ID NO:243;
(k′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:109, a CDR2 comprising SEQ ID NO:110 and a CDR3 comprising SEQ ID NO:111 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:244, a CDR2 comprising SEQ ID NO:245 and a CDR3 comprising SEQ ID NO:246;
(l′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:112, a CDR2 comprising SEQ ID NO:113 and a CDR3 comprising SEQ ID NO:114 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:247, a CDR2 comprising SEQ ID NO:248 and a CDR3 comprising SEQ ID NO:249;
(m′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:115, a CDR2 comprising SEQ ID NO:116 and a CDR3 comprising SEQ ID NO:117 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:250, a CDR2 comprising SEQ ID NO:251 and a CDR3 comprising SEQ ID NO:252;
(n′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:118, a CDR2 comprising SEQ ID NO:119 and a CDR3 comprising SEQ ID NO:120 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:253, a CDR2 comprising SEQ ID NO:254 and a CDR3 comprising SEQ ID NO:255;
(o′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:121, a CDR2 comprising SEQ ID NO:122 and a CDR3 comprising SEQ ID NO:123 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:256, a CDR2 comprising SEQ ID NO:257 and a CDR3 comprising SEQ ID NO:258;
(p′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:124, a CDR2 comprising SEQ ID NO:125 and a CDR3 comprising SEQ ID NO:126 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:259, a CDR2 comprising SEQ ID NO:260 and a CDR3 comprising SEQ ID NO:261;
(q′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:127, a CDR2 comprising SEQ ID NO:128 and a CDR3 comprising SEQ ID NO:129 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:262, a CDR2 comprising SEQ ID NO:263 and a CDR3 comprising SEQ ID NO:264;
(r′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:130, a CDR2 comprising SEQ ID NO:131 and a CDR3 comprising SEQ ID NO:132 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:265, a CDR2 comprising SEQ ID NO:266 and a CDR3 comprising SEQ ID NO:267;
and
(s′) a light chain variable region comprising a CDR1 comprising SEQ ID NO:133, a CDR2 comprising SEQ ID NO:134 and a CDR3 comprising SEQ ID NO:135 and a heavy chain variable region comprising a CDR1 comprising SEQ ID NO:268, a CDR2 comprising SEQ ID NO:269 and a CDR3 comprising SEQ ID NO:270;
wherein the antigen binding protein specifically binds to cytomegalovirus (CMV).

44 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/897,374Filed 9 Jun 2014 · us provisional application
Priority: 10 Jun 2013
Published: US 2016/0130327 A112 May 2016
Granted: 16 Jan 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07K 16/089
Orthoherpesviridae , e.g. pseudorabies virus or Epstein-Barr virus: cytomegalovirus
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
C07K 2317/24
Characterized by taxonomic origin: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/565
Variable region, i.e. VH and/or VL: complementarity determining region [CDR]

Family

Application61/833,184Us provisional application · filed 10 Jun 2013
US 2016/0130327 A1Pre-grant publication · published 12 May 2016
US 9,868,777 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A recombinant antigen binding protein comprising a heavy chain variable region comprising a CDR1, CDR2 and CDR3 selected from the group consisting of:

(h-a) a CDR1 comprising SEQ ID NO:136, a CDR2 comprising SEQ ID NO:137 and a CDR3 comprising SEQ ID NO:138;
(h-b) a CDR1 comprising SEQ ID NO:139, a CDR2 comprising SEQ ID NO:140 and a CDR3 comprising SEQ ID NO:141;
(h-c) a CDR1 comprising SEQ ID NO:142, a CDR2 comprising SEQ ID NO:143 and a CDR3 comprising SEQ ID NO:144;
(h-d) a CDR1 comprising SEQ ID NO:145, a CDR2 comprising SEQ ID NO:146 and a CDR3 comprising SEQ ID NO:147;
(h-e) a CDR1 comprising SEQ ID NO:148, a CDR2 comprising SEQ ID NO:149 and a CDR3 comprising SEQ ID NO:150;
(h-f) a CDR1 comprising SEQ ID NO:151, a CDR2 comprising SEQ ID NO:152 and a CDR3 comprising SEQ ID NO:153;
(h-g) a CDR1 comprising SEQ ID NO:154, a CDR2 comprising SEQ ID NO:155 and a CDR3 comprising SEQ ID NO:156;
(h-h) a CDR1 comprising SEQ ID NO:157, a CDR2 comprising SEQ ID NO:158 and a CDR3 comprising SEQ ID NO:159;
(h-i) a CDR1 comprising SEQ ID NO:160, a CDR2 comprising SEQ ID NO:161 and a CDR3 comprising SEQ ID NO:162;
(h-j) a CDR1 comprising SEQ ID NO:163, a CDR2 comprising SEQ ID NO:164 and a CDR3 comprising SEQ ID NO:165;
(h-k) a CDR1 comprising SEQ ID NO:166, a CDR2 comprising SEQ ID NO:167 and a CDR3 comprising SEQ ID NO:168;
(h-l) a CDR1 comprising SEQ ID NO:169, a CDR2 comprising SEQ ID NO:170 and a CDR3 comprising SEQ ID NO:171;
(h-m) a CDR1 comprising SEQ ID NO:172, a CDR2 comprising SEQ ID NO:173 and a CDR3 comprising SEQ ID NO:174;
(h-n) a CDR1 comprising SEQ ID NO:175, a CDR2 comprising SEQ ID NO:176 and a CDR3 comprising SEQ ID NO:177;
(h-o) a CDR1 comprising SEQ ID NO:178, a CDR2 comprising SEQ ID NO:179 and a CDR3 comprising SEQ ID NO:180;
(h-p) a CDR1 comprising SEQ ID NO:181, a CDR2 comprising SEQ ID NO:182 and a CDR3 comprising SEQ ID NO:183;
(h-q) a CDR1 comprising SEQ ID NO:184, a CDR2 comprising SEQ ID NO:185 and a CDR3 comprising SEQ ID NO:186;
(h-r) a CDR1 comprising SEQ ID NO:187, a CDR2 comprising SEQ ID NO:188 and a CDR3 comprising SEQ ID NO:189;
(h-s) a CDR1 comprising SEQ ID NO:190, a CDR2 comprising SEQ ID NO:191 and a CDR3 comprising SEQ ID NO:192;
(h-t) a CDR1 comprising SEQ ID NO:193, a CDR2 comprising SEQ ID NO:194 and a CDR3 comprising SEQ ID NO:195;
(h-u) a CDR1 comprising SEQ ID NO:196, a CDR2 comprising SEQ ID NO:197 and a CDR3 comprising SEQ ID NO:198;
(h-v) a CDR1 comprising SEQ ID NO:199, a CDR2 comprising SEQ ID NO:200 and a CDR3 comprising SEQ ID NO:201;
(h-w) a CDR1 comprising SEQ ID NO:202, a CDR2 comprising SEQ ID NO:203 and a CDR3 comprising SEQ ID NO:204;
(h-x) a CDR1 comprising SEQ ID NO:205, a CDR2 comprising SEQ ID NO:206 and a CDR3 comprising SEQ ID NO:207;
(h-y) a CDR1 comprising SEQ ID NO:208, a CDR2 comprising SEQ ID NO:209 and a CDR3 comprising SEQ ID NO:210;
(h-z) a CDR1 comprising SEQ ID NO:211, a CDR2 comprising SEQ ID NO:212 and a CDR3 comprising SEQ ID NO:213;
(h-a′) a CDR1 comprising SEQ ID NO:214, a CDR2 comprising SEQ ID NO:215 and a CDR3 comprising SEQ ID NO:216;
(h-b′) a CDR1 comprising SEQ ID NO:217, a CDR2 comprising SEQ ID NO:218 and a CDR3 comprising SEQ ID NO:219;
(h-c′) a CDR1 comprising SEQ ID NO:220, a CDR2 comprising SEQ ID NO:221 and a CDR3 comprising SEQ ID NO:222;
(h-d′) a CDR1 comprising SEQ ID NO:223, a CDR2 comprising SEQ ID NO:224 and a CDR3 comprising SEQ ID NO:225;
(h-e′) a CDR1 comprising SEQ ID NO:226, a CDR2 comprising SEQ ID NO:227 and a CDR3 comprising SEQ ID NO:228;
(h-f′) a CDR1 comprising SEQ ID NO:229, a CDR2 comprising SEQ ID NO:230 and a CDR3 comprising SEQ ID NO:231;
(h-g′) a CDR1 comprising SEQ ID NO:232, a CDR2 comprising SEQ ID NO:233 and a CDR3 comprising SEQ ID NO:234;
(h-h′) a CDR1 comprising SEQ ID NO:235, a CDR2 comprising SEQ ID NO:236 and a CDR3 comprising SEQ ID NO:237;
(h-i′) a CDR1 comprising SEQ ID NO:238, a CDR2 comprising SEQ ID NO:239 and a CDR3 comprising SEQ ID NO:240;
(h-j′) a CDR1 comprising SEQ ID NO:241, a CDR2 comprising SEQ ID NO:242 and a CDR3 comprising SEQ ID NO:243;
(h-k′) a CDR1 comprising SEQ ID NO:244, a CDR2 comprising SEQ ID NO:245 and a CDR3 comprising SEQ ID NO:246;
(h-l′) a CDR1 comprising SEQ ID NO:247, a CDR2 comprising SEQ ID NO:248 and a CDR3 comprising SEQ ID NO:249;
(h-m′) a CDR1 comprising SEQ ID NO:250, a CDR2 comprising SEQ ID NO:251 and a CDR3 comprising SEQ ID NO:252;
(h-n′) a CDR1 comprising SEQ ID NO:253, a CDR2 comprising SEQ ID NO:254 and a CDR3 comprising SEQ ID NO:255;
(h-o′) a CDR1 comprising SEQ ID NO:256, a CDR2 comprising SEQ ID NO:257 and a CDR3 comprising SEQ ID NO:258;
(h-p′) a CDR1 comprising SEQ ID NO:259, a CDR2 comprising SEQ ID NO:260 and a CDR3 comprising SEQ ID NO:261;
(h-q′) a CDR1 comprising SEQ ID NO:262, a CDR2 comprising SEQ ID NO:263 and a CDR3 comprising SEQ ID NO:264;
(h-r′) a CDR1 comprising SEQ ID NO:265, a CDR2 comprising SEQ ID NO:266 and a CDR3 comprising SEQ ID NO:267;
and
(h-s′) a CDR1 comprising SEQ ID NO:268, a CDR2 comprising SEQ ID NO:269 and a CDR3 comprising SEQ ID NO:270;
wherein the antigen binding protein specifically binds to CMV.

44 more elements

Facts

Application

14/897,374Filed 9 Jun 2014 · us provisional application

Priority

10 Jun 2013

Published

US 2016/0130327 A112 May 2016

Granted

16 Jan 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07K 16/089
Orthoherpesviridae , e.g. pseudorabies virus or Epstein-Barr virus: cytomegalovirus
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
C07K 2317/24
Characterized by taxonomic origin: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/565
Variable region, i.e. VH and/or VL: complementarity determining region [CDR]