Analogs of glucagon exhibiting GIP receptor activity
AssigneeIndiana University Research and Technology Corporation
InventorsRichard D. Dimarchi, David L. Smiley, Konrad H. Bleicher, Eric A. Kitas
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Abstract
Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.
Claims3
A glucagon analog exhibiting glucagon, GLP-1 and GIP receptor activity, said analog consisting of the sequence of SEQ ID NO:
- 12.
A glucagon analog exhibiting glucagon, GLP-1 and GIP receptor activity, said analog selected from the group consisting of SEQ ID NO:
- 12, SEQ ID NO:
- 13, SEQ ID NO:
- 17, SEQ ID NO:
- 143 and SEQ ID NO:
- 146.
Dependencies are inferred from the claim text.