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US 9,868,767 B2Granted
Chemical synthesis and screening of bicyclic peptide libraries
AssigneeOhio State Innovation Foundation
InventorsDehua Pei, Punit Upadhyaya, Wenlong Lian, Thi Trinh
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Abstract
Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims19
A compound of Formula I-A:
- wherein
- Xm and Xn independently comprise a sequence of 1-10 amino acids;
- R0 is selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, or linker to solid phase support;
- and
- K has a structure represented by a formula:
2 more elements
A compound comprising:
- a. a residue of trimesic acid, the residue bearing three carboxyl functionalities;
- b. a lysine residue covalently bonded to the first carboxyl functionality of the trimesic acid residue;
- c. a first peptide chain of 1-10 amino acid residues, Xm, covalently bonded to the second carboxyl functionality of the trimesic acid residue and to the lysine residue;
- and
- d. a second peptide chain of 1-10 amino acid residues, Xn, covalently bonded to the third carboxyl functionality of the trimesic acid residue and to the lysine residue.
2 more elements
Dependencies are inferred from the claim text.