Solid phase peptides synthesis processes and associated systems
AssigneeMassachusetts Institute of Technology
InventorsMark David Simon, Bradley L. Pentelute, Andrea Adamo, Patrick Louis Heider, Klavs F. Jensen
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Abstract
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.
Claims19
A process for adding amino acid residues to peptides, comprising:
- flowing a first stream comprising amino acids;
- flowing a second stream comprising an amino acid activating agent;
- merging the first and second streams to form a mixed fluid comprising activated amino acids;
- and
- within about 30 seconds after merging the first and second streams to fotra the mixed fluid, exposing the mixed fluid to a plurality of peptides immobilized on a solid support.
Dependencies are inferred from the claim text.