5-β, 14-β-androstane derivatives useful for the treatment of proteinuria, glomerulosclerosis and renal failure
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsPatrizia Ferrari, Giuseppe Bianchi, Mara Ferrandi
Life of this patent
Estimating the term…
Abstract
Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of proteinuria, glomerulosclerosis or renal failure.
Claims8
A method for treating proteinuria, comprising the step of administering to a normotensive patient in need thereof a therapeutically effective amount of a compound of formula (I),
- wherein:
- the symbol represents a single bond;
- Y is OR4 and has an alpha or a beta configuration;
- R is 3-furyl;
- R1 is hydrogen;
- R2 is hydrogen;
- R3 is hydrogen;
- R4 is hydrogen.
A method of antagonizing podocyte protein loss in a normotensive patient in need thereof, which comprises administering to said patient a therapeutically effective amount of a compound of formula (I),
- wherein:
- the symbol represents a single bond;
- Y is OR4 and has an alpha or a beta configuration;
- R is 3-furyl;
- R1 is hydrogen;
- R2 is hydrogen;
- R3 is hydrogen;
- R4 is hydrogen.
Dependencies are inferred from the claim text.