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US 9,868,747 B2Granted
Marinopyrrole derivatives and methods of making and using same
AssigneesH. Lee Moffitt Cancer Center and Research Institute, Inc., Chongqing Zein Pharmaceutical Co., Ltd
InventorsRongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
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Abstract
Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
Claims20
A compound of the following structure:
- wherein each R6, R7, R13, and R14 are independently chosen from hydrogen, halogen, and hydroxyl;
- R5 and R12 are independently chosen from hydrogen, halogen, and substituted or unsubstituted alkyl;
- R2, R9, R18 and R19 are independently chosen from hydrogen, halogen, hydroxyl, cyano, nitro, substituted or unsubstituted sulfonate, substituted or unsubstituted phosphonate, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heteroalkenyl, substituted or unsubstituted heterocycloalkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted heteroalkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkoxyl, substituted or unsubstituted aryloxyl, and substituted or unsubstituted carboxyl;
- or pharmaceutically acceptable salts thereof.
1 more element
Dependencies are inferred from the claim text.