Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4

A compound having a structure represented by a formula:

• wherein:
• each of R3a and R3b is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C3-C9 cycloalkyl, C2-C7 heterocycloalkyl, (C1-C8 alkyl)(C3-C9 cycloalkyl), and —(C1-C8 alkyl)-(C2-C7 heterocycloalkyl);
• wherein R3a and R3b are optionally covalently bonded and, together with the intermediate nitrogen, form a 3- to 7-membered heterocycloalkyl substituted with 0, 1, 2, or 3 groups independently selected from halogen, —NH2, —OH, —CN, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, and C1-C6 dialkylamino;
• m is an integer from 1 to 3;
• Ar1 is selected from phenyl and heterocyclyl, and Ar1 is substituted with 0-2 groups selected from halogen, —NH2, —OH, —CN, C1-C8 alkyl, C1-C8 haloalkyl, C1-C8 polyhaloalkyl, C1-C8 alkoxy, C1-C8 alkylamino, C1-C8 dialkylamino, and —S(O)nR5;
• n is an integer from 0 to 2;
• and
• R5, when present, is selected from hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, and C1-C8 polyhaloalkyl;
• or a pharmaceutically acceptable salt, solvate, or polymorph thereof.