Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b] pyridazines, related compounds, and their use in the treatment of medical disorders
AssigneeLysosomal Therapeutics Inc.
InventorsRenato T. Skerlj, Elyse Marie Josee Bourque, Peter T. Lansbury
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Abstract
The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine compounds, related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,2-b]pyridazine compounds described herein include substituted imidazo[1,2-b]pyridazine-3-carboxamide compounds and variants thereof.
Claims30
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1A is 6-membered aryl substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, and cyano;
- R1B is C1-C6 alkyl;
- R2 is hydrogen;
- R3 is hydrogen;
- R4 is one of the following:
- C3-C8 cycloalkyl optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of C1-C6 alkyl, halogen, C1-C6 haloalkyl, C3-C6 cycloalkyl, hydroxyl, C1-C6 alkoxy, C2-C4 alkynyl, and —(C2-C4 alkynyl)-C1-C6 alkoxy;
- or
- C1-6 alkyl;
- Y is C1-C6 haloalkylene or C1-C6 alkylene;
- and
- n is 1.
A compound of Formula I-B:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1A is 6-membered aryl substituted with 1 or 2 substituents independently selected from fluorine and cyano;
- R1B and R2 are hydrogen;
- R1C is C1-C6 alkyl;
- R3 is hydrogen;
- R4 is (i) C3-C8 cycloalkyl optionally substituted by 1, 2, or 3 substituents independently selected from the group consisting of C1-C8 alkyl, C1-C6 haloalkyl, and C1-C6 alkoxy, or (ii) C1-C6 alkyl;
- and
- Y is C1-C6 alkylene or C1-C6 haloalkylene.
A compound having the following formula or a pharmaceutically acceptable salt thereof:
A compound having the following formula or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.