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US 9,868,736 B2Granted
Deubiquitinase inhibitors and methods for use of the same
AssigneeThe Regents of the University of Michigan
InventorsNicholas J. Donato, Moshe Talpaz, Luke Peterson, Matthew Young, Hollis D. Showalter, Christiane Wobus, Mary Xuan Dziem O'Riordan, Monika Ermann
Life of this patent
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Abstract
Disclosed herein are methods of inhibiting a deubiquitinase (DUB) by contact with a compound of formula (I).
Claims22
A compound having a formula (I):
- wherein
- R1 and R2 together form an optionally substituted aryl ring or heteroaryl ring, and R3 is halo or hydrogen;
- R4 is C2-C6alkyl or C1-C6alkylenearyl;
- and
- (a) one of R5 and R5′ is hydrogen and the other substituted alkoxy, or (b) each of R5 and R5′ is substituted alkoxy, or (c) when the ring formed by R1 and R2 together is an aryl ring which is substituted, or is a heteroaryl ring which is optionally substituted, then R5 and R5′ can each be hydrogen;
- or a salt or solvate thereof.
3 more elements
A compound of having a structure
- or a salt or solvate thereof.
A compound having a structure
- or a salt or solvate thereof.
A compound having the structure
- or a salt or solvate thereof.
Dependencies are inferred from the claim text.