Benzazepine ketone compounds as glycogen phosphorylase inhibitor, preparation method therefor, and medical uses
AssigneeChengde Medical University
InventorLiying Zhang
Life of this patent
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Abstract
The present invention relates to the field of pharmaceutical chemistry, and particularly to a novel class of benzazepine ketone derivatives (I), their preparation method and their pharmaceutical uses. The compounds have glycogen phosphorylase inhibiting effect and can be used in the preparation of anti-diabetes and its complications medicaments, anti-cerebral ischemia medicaments, anti-cardiovascular diseases medicaments, blood lipid-lowering medicaments, weight-reducing medicaments, anti-atherosclerosis medicaments, medicaments for treating metabolic syndrome or anti-tumor medicaments. The present invention also relates to a preparation method of the class of compounds and pharmaceutical formulations containing the same.
Claims11
A compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof:
- wherein,
- all of X1, X2, X3 and X4 are C, or one of X1, X2, X3 and X4 is N and all the others are C;
- each of R1 and R1′, independently, is H, halogen, hydroxy, cyano, C0-4 alkyl, C1-4 alkoxy, fluoromethyl, difluoromethyl, trifluoromethyl, ethenyl, or ethynyl;
- each of R2 and R2′, independently, is H, halogen, hydroxy, cyano, C0-4 alkyl, C1-4 alkoxy, fluoromethyl, difluoromethyl, trifluoromethyl, ethenyl, or ethynyl;
- R3 is H, unsubstituted or X-substituted linear or branched C1-20 alkyl, unsubstituted or X-substituted linear or branched C1-20 alkenyl, unsubstituted or X-substituted linear or branched C1-20 alkynyl, substituted or X-substituted aryl, or substituted or X-substituted heteroaryl;
- each of R4 and R5, independently, is H, unsubstituted or X-substituted linear or branched C1-20 alkyl, unsubstituted or X-substituted linear or branched C1-20 alkenyl, or unsubstituted or X-substituted linear or branched C1-20 alkynyl;
- Y is CHR6, NH, O, or S;
- R6 is H, unsubstituted or X-substituted linear or branched C1-20 alkyl, unsubstituted or X-substituted linear or branched C1-20 alkenyl, unsubstituted or X-substituted linear or branched C1-20 alkynyl, phenyl, benzyl, naphthyl, or nitrile group;
- X represents H, F, Cl, Br, I, CN, NO2, NH2, CF3, SH, OH, OCH3, OC2H5, COOH, linear or branched C1-10 alkyl, linear or branched C1-10 alkenyl, linear or branched C1-10 alkynyl, aryl, or heteroaryl.
Dependencies are inferred from the claim text.