Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof
AssigneeLuoda Biosciences, Inc.
InventorsQizheng Yao, Jiajia Liu, Zhaohui Wang, Kui Wu, Yongbin Wang, Shining Yao, Ruihuan Chen, Beibei Yang
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Abstract
The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.
Claims13
A compound of formula I-1 or formula II-1, or an enantiomer, a racemate, a cis-trans isomer or any combination thereof, or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 is selected from the group consisting of H, D, or the following groups that may be unsubstituted or substituted by 1 to 3 substituents:
- C1˜C6 alkyl, aryl, aralkyl, acyl, glycosyl protected by acyl, or glycosyl;
- wherein said substituents are selected from the group consisting of halogen, hydroxyl, C1˜C3 alkyl, nitro or amino;
- R2, R2′, R4′ and R5′ are H;
- R3 is selected from the group consisting of H, halo, and C1˜C4 alkyl;
- R4 is selected from the group consisting of H, halo, and C1˜C4 alkyl;
- R5 is selected from the group consisting of H, halo, and C1˜C4 alkyl;
- R3′ is selected from the group consisting of H, halo, C1˜C4 alkoxyl and C1˜C4 alkyl;
- and
- R is selected from the group consisting of oxygen, sulfur, selenium, or NOR6 group, wherein R6 is H or C1˜C6 straight-chain or branched-chain alkyl.
Dependencies are inferred from the claim text.