Apigenin analogs, compositions, and methods related thereto
AssigneeBoard of Regents, The University of Texas Systems
InventorsJia Zhou, Mark Hellmich, Csaba Szabo
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Abstract
Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (CBS) inhibitors. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents. Certain embodiments are directed methods of treating or compositions used to treat fibrosis and cancers. In certain aspects one or more compounds described herein can be administered to a subject to treat pancreatic fibrosis, liver fibrosis, pancreatic cancer, colon cancer, breast cancer, brain tumors, head/neck cancer, prostate and lung cancers as well as other inflammation.
Claims6
Certain embodiments are directed to compounds having the general formula of Formula II:
- where X is O;
- n is 1, 2, 3, 4, or 5;
- R1, R3, and R5 are hydrogen;
- R2 and R4 are methoxy;
- and
- R7 is a C1-C6 hydroxyalkyl substituted by a 3 to 8 membered heterocycle, or a 3 to 8 membered heterocycle.
Dependencies are inferred from the claim text.