US 9,868,695 B2 · 10-substituted colchicinoids as potent anticancer agents

10-substituted colchicinoids as potent anticancer agents

AssigneeCouncil of Scientific and Industrial Research

InventorsRam A. Vishwakarma, Sandip B. Bharate, Ajay Kumar, Baljinder Singh, Ashok Kumar, Shashi Bhushan, Abid Hamid, Prashant Joshi, Santosh K. Guru, Suresh Kumar, Aashiq Hussain, Asif K. Qazi, Sonali S. Bharate, Parduman Sharma, Ajit K. Saxena, Dilip M. Mondhe, Girish Mahajan, Zahoor Wani

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Abstract

The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.

Claims7

Dependent claims

A 10-substituted colchicinoid compound represented by the formula 1g

Dependencies are inferred from the claim text.

Facts

Application

15/519,054Filed 14 Oct 2015

Priority

IN 2929/DEL/201414 Oct 2014

Published

US 2017/0226051 A110 Aug 2017

Granted

16 Jan 2018

Term ends

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Classification8 codes

C07C 233/41
Having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups:…
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide
A61P 35/00
Antineoplastic agents
C07C 231/12
Preparation of carboxylic acid amides: by reactions not involving the formation of carboxamide groups