US 9,868,690 B2Granted

Prodrugs of monomethyl fumarate (MMF)

Assigneeratiopharm GmbH

InventorsWolfgang Albrecht, Roland Selig, Sebastian Rabe, Richard Guserle, Annemarie Maier

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Abstract

The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (MMF) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis.

Claims12

Dependent claims

A compound according to any one of the following Formulae (I) to (VI) or mixtures thereof for use as a medicament:

wherein
L is an alkanediyl group with 1 to 6 carbon atoms, and
A is SO, SO2 or NR1, wherein R1 is isopropyl or a cycloalkyl with 3, 5 or 6 carbon atoms.

Dependencies are inferred from the claim text.

Facts

Application: 14/647,677Filed 20 Dec 2013
Published: US 2015/0299103 A122 Oct 2015
Granted: 16 Jan 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification17 codes

C07C 225/22
Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms…:…
A61K 31/225
Of acyclic acids, e.g. pravastatin: polycarboxylic acids
A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…
A61K 31/54
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with at least one nitrogen and one sulfur as the…

Family

US 2015/0299103 A1Pre-grant publication · published 22 Oct 2015
US 9,868,690 B2This patent

From the US filing history. Foreign family members aren’t listed.

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