Apparatus and method for treating tissue

A method for treating mammalian esophageal tissue with a flexible elongate member having a distal extremity provided with a recess, comprising:

• introducing the distal extremity into the body adjacent the esophageal tissue through an insertion tube;
• drawing the esophageal tissue in the recess using suction;
• advancing a needle from a first position within the distal extremity to a second position within the recess and into the esophageal tissue captured in the recess, wherein the recess is capable of relative movement between a first position in which the recess is disposed within the insertion tube and a second position in which the recess is accessible distally of the insertion tube;
• and
• injecting a material through the needle into the esophageal tissue in the recess, wherein a travel distance of the needle between the first and second positions ranges from 4 to 25 millimeters.

A method for treating mammalian esophageal tissue with a flexible elongate member having a distal extremity provided with a nozzle, comprising:

• introducing the distal extremity into the body adjacent the esophageal tissue through an insertion tube;
• capturing the esophageal tissue in a recess within the nozzle;
• and
• injecting a material through an outlet orifice of the nozzle into the esophageal tissue in the recess, wherein a diameter of the outlet orifice is less than an inner diameter of the flexible elongate member, wherein the recess is capable of relative movement between a first position in which the nozzle is disposed within the insertion tube and a second position in which the recess is accessible distally of the insertion tube.