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US 9,867,909 B2Granted
Multilayer implants for delivery of therapeutic agents
AssigneeSofradim Production
InventorSébastien Ladet
Life of this patent
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Abstract
Enzymatically degradable compositions containing biocompatible polymers reactive with glycosaminoglycan compositions having a first glycosaminoglycan having a first degree of acetylation and a second glycosaminoglycan having a second degree acetylation different than the first degree of acetylation.
Claims23
A multilayer implant for delivery of a therapeutic agent comprising:
- a first non-porous film layer comprising a first glycosaminoglycan composition including a first chitosan having a first degree of acetylation, the first chitosan covalently bonded to a poly(ethylene glycol) functionalized to include pendant electrophilic groups,
- a second layer comprising a second glycosaminoglycan composition comprising at least one second chitosan having a second degree acetylation different than the first degree of acetylation wherein at least one of the first and second layers further comprises a therapeutic agent.
A multilayer implant for delivery of a therapeutic agent comprising:
- a first non-porous film layer comprising a first glycosaminoglycan composition including a first chitosan having a first degree of acetylation and a second chitosan having a second degree acetylation different than the first degree of acetylation, at least one of the first and second chitosans covalently bonded to a poly(ethylene glycol) functionalized to include pendant electrophilic groups
- a second layer comprising a second glycosaminoglycan composition comprising a third glycosaminoglycan having a third degree acetylation and a fourth glycosaminoglycan having a fourth degree acetylation different than the third degree of acetylation wherein at least one of the first and second layers further comprises a therapeutic agent.
Dependencies are inferred from the claim text.