Isatoic anhydride derivatives and applications thereof
AssigneeThe University of North Carolina at Charlotte
InventorsCraig A. Ogle, Anthony J. Fowler
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Abstract
Isatoic anhydride derivatives having an N-substituent which includes a quaternary ammonium group are useful for labeling and/or functionalizing a target material and/or for coupling materials together. The isatoic anhydride derivatives of the present disclosure can be advantageously water soluble, easily prepared and purified. Isatoic anhydride derivatives useful in the present disclosure preferably have at least one chemically reactive group or at least one binding group or at least one detectable label. Anthranilate derivatives made from the isatoic anhydrides derivatives or otherwise and kits including the isatoic anhydride derivatives are also disclosed.
Claims8
An isatoic anhydride derivative having the following formula:
- wherein V, W, Y, and Z individually represent H, N3, NO2, amino, alkylamino, dialkylamino, branched or linear alkyl, branched or linear alkenyl, branched or linear alkynyl, branched or linear alkoxy, branched or linear sulfenyl, an alkyne or azido substituted alkylamino, dialkylamino, alkyl, aikoxy, sulfenyl, formyl, acetyl, or halide;
- L1 represents a linker group;
- R3 and R4, independently represent a linear or branched alkyl, an alkyl ether, or together form a cyclic heteroalkyl, or cyclic heteroaryl;
- Q− represents an anion;
- p is an integer from 0 to 2;
- when p is 0, L2 represents a pendant organo group;
- when p greater than 0, L2 represents a second independent linker group;
- R1 represents a chemically reactive group, a binding group, or a detectable label.
Dependencies are inferred from the claim text.