Methods and compositions for modulating the immune system with Arginase I
AssigneeBio-Cancer Treatment International Limited
InventorsGernot Schabbauer, Stephen Bluml, Emine Sahin-Heco, Paul Cheng, Li Chen
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Abstract
Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject.
Claims30
A method of treating rheumatoid arthritis in a subject in need thereof, the method comprising administering to the subject suffering from rheumatoid arthritis a therapeutically-effective amount of a purified pegylated Arginase I or a functional fragment thereof, wherein the purified pegylated Arginase I or functional fragment thereof treats the rheumatoid arthritis by inhibiting T-cell polarization.
A method of treating rheumatoid arthritis in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a purified pegylated Arginase I or a functional fragment thereof, wherein the purified pegylated Arginase I or the functional fragment thereof reduces a pain associated with rheumatoid arthritis in the subject.
A method of treating rheumatoid arthritis in a subject in need thereof, the method comprising administering to the subject a composition comprising a purified pegylated human Arginase I, wherein the purified pegylated human Arginase I comprises an amino acid sequence selected from the group consisting of:
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Dependencies are inferred from the claim text.