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US 9,867,845 B2Granted
Vectors for delivery of agents across biological membranes
AssigneeThe Regents of the University of California
InventorsZhibin Guan, Hanxiang Zeng, Mark Edward Johnson
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Abstract
The disclosure provides for peptide-based bolaamphiphile vectors that are capable of encapsulating a variety of agents, including peptides, proteins, nucleic acids, and drugs. The disclosure further provides for delivering these agents across biological membranes using the peptide-based bolaamphiphile vectors.
Claims21
A compound comprising the formula:
- D1-(L1)x-C-(L2)y-D2
- wherein,
- D1 and D2 are dendritic hydrophilic head groups comprising a plurality of branched peptides, wherein each head group comprises two to six generations of branching;
- C is a linear hydrophobic core comprising an optionally substituted linear (C6 to C25)alkyl, an optionally substituted linear (C6 to C25)heteroalkyl, an optionally substituted linear (C6 to C25)alkenyl, an optionally substituted linear (C6 to C25)heteroalkenyl, an optionally substituted linear (C6 to C25)alkynyl, or an optionally substituted linear (C6 to C26)heteroalkynyl,
- L1 and L2 are linkers which comprise a biodegradable group that is capable of being cleaved in the cytoplasm of a cell;
- x is an integer selected from 0 to 5;
- y is an integer selected from 0 to 5, and
- wherein the compound contains only two dendritic hydrophilic head groups.
5 more elements
Dependencies are inferred from the claim text.