Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells

A method for mobilizing cells from the bone marrow in a subject comprising administering to the subject a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of formula (I):

• or a pharmaceutically acceptable salt, isomer, tautomer, hydrate or solvate thereof, wherein:
• R1 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl or C2-C8 haloalkynyl;
• R2 is a linker-non-glycomimetic moiety, wherein the non-glycomimetic moiety comprises polyethylene glycol;
• R3 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl, C2-C8 haloalkynyl or cyclopropyl;
• R4 is —OH or —NZ1Z2, wherein Z1 and Z2 are each independently H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl or C2-C8 haloalkynyl or wherein Z1 and Z2 join to form a ring;
• R5 is C3-C8 cycloalkyl;
• R6 is —OH, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl or C2-C8 haloalkynyl;
• R7 is —CH2OH, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl or C2-C8 haloalkynyl;
• and
• R8 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 haloalkyl, C2-C8 haloalkenyl or C2-C8 haloalkynyl.