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US 9,867,838 B2Granted
Methods for treating heart failure using bisphosphonate compositions
AssigneeDuke University
InventorsKenneth W. Lyles, Cathleen S. Colon-Emeric, Christopher M. O'Connor, Richard S. Stack, Colleen Stack
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Abstract
The present invention provides for methods for treating and/or reducing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.
Claims19
A method of treating cardiac dysfunctions due to heart failure in a subject experiencing decreased ejection fraction, said method comprising:
- administering to said subject a dosage of a bisphosphonate or a pharmaceutically effective salt thereof, wherein the bisphosphonate is zoledronic acid, wherein the dosage is in a therapeutic amount from about 40 ug/kg to about 125 ug/kg to provide an increase in the ejection fraction in the subject after administration of the bisphosphonate.
A method of increasing ejection fraction in a subject experiencing such cardiac dysfunctions, said method comprising:
- administering to said subject a dosage of zoledronic acid or a pharmaceutically effective salt thereof, wherein the dosage is in a therapeutic amount from about 40 ug/kg to about 125 ug/kg to increase ejection fraction from about 10 to about 20% in the subject.
Dependencies are inferred from the claim text.