Methods and formulations for topical treatment of psoriasis

A formulation for topical treatment of psoriasis in a patient or subject, comprising a therapeutically effective amount of pemetrexed and a therapeutically effective amount of siRNA-inhibiting TNFα in combination with said pemetrexed.

A method of reducing one or more symptoms associated with a patient or subject suffering from psoriasis, where said one or more symptoms are selected from the group consisting of erythema, scaling, plaque epidermal thickening, rete ridge elongation, inflammation, and a combination thereof, the method comprising topically administering to said patient or subject a formulation containing therapeutically effective amounts of pemetrexed, siRNA inhibiting TNFα, urea, and cetylpyridinum chloride as a cationic surfactant, wherein said urea and said cetylpyridinum chloride increase permeation of said pemetrexed and said siRNA inhibiting TNFα through a stratum corneum of said patient or subject for enhanced skin deposition in said patient or subject, wherein said formulation further includes a fusogenic nanocarrier bound to said siRNA-inhibiting TNFα to internalize and transfect said siRNA-inhibiting TNFα, wherein said topical administration is performed by applying said formulation onto a psoriatic patch of skin of said patient or subject that is suffering from psoriasis.