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US 9,867,824 B2Granted
Heterocyclic compounds and uses thereof
AssigneeCelgene CAR LLC
InventorsKwangho Lee, Deqiang Niu, Russell C. Petter, Matthew Frank Baevsky, Juswinder Singh
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Abstract
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Claims14
A method for treating a proliferative disorder comprising administering to a patient in need thereof a compound represented by structural formula I-a
- or a pharmaceutically acceptable salt thereof, wherein:
- n is 0, 1, or 2;
- m is 0, 1, or 2, wherein m and n are not simultaneously 0;
- W is —O— or —NH—;
- R1 is —OR;
- each R is independently C1-4 alkyl or C1-4 fluoroalkyl;
- R2 is —CF3, Cl, or Br;
- G is —NR3— or —S(O)2—;
- and
- R3 is —C(O)—R, —C(O)OR, —C(O)NHR, —SO2—R, —SO2NH2, —C(O)—C1-4 alkylene-OH or —SO2—C1-4 alkylene-OH;
- and
- wherein the proliferative disorder is a cancer.
9 more elements
Dependencies are inferred from the claim text.