US 9,867,811 B2 · Method of treating atherosclerosis in high triglyceride subjects

Abstract

The present invention provides a compound of Formula I: for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R1, X1, R7, R5, C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.

Claims12

Dependent claims

A method of treating or ameliorating atherosclerosis by raising HDL-C and/or lowering LDL-C, in a subject comprising, administering to the subject a therapeutically effective amount of the following compound:

or a pharmaceutically acceptable salt thereof, wherein the subject's triglyceride level is a fasting triglyceride level greater than 500 mg/dL.

Dependencies are inferred from the claim text.

Facts

Application

14/128,877Filed 6 Jul 2012 · us provisional application

Priority

8 Jul 2011

Published

US 2014/0134262 A115 May 2014

Granted

16 Jan 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/421
Oxazoles: 1,3-Oxazoles, e.g. pemoline, trimethadione
A61K 31/41
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having five-membered rings with two or more ring hetero atoms, at least…
A61K 31/44
Having six-membered rings with one nitrogen as the only ring hetero atom: non condensed pyridines; Hydrogenated derivatives thereof
A61K 31/4439
Containing further heterocyclic ring systems: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Method of treating atherosclerosis in high triglyceride subjects

Life of this patent

Method of treating atherosclerosis in high triglyceride subjects

Life of this patent

Abstract

Claims12