Amorphous solid dispersion comprising taxane, tablet comprising the same, and method for preparing the same
AssigneeHanmi Pharm. Co., Ltd.
InventorsShanmugam Srinivasan, Ho Taek Im, Young Su Yoon, Yong Il Kim, Jae Hyun Park, Jong Soo Woo
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Abstract
Provided is an amorphous solid dispersion including a taxane or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable polymer, and a pharmaceutically acceptable surfactant, which has enhanced solubility. Also provided is a method for preparing the solid dispersion. The present subject matter also provides a tablet having good solubility, bioavailability and stability, which comprises the amorphous solid dispersion, an intragranular excipient, and an extragranular excipient.
Claims33
An amorphous solid dispersion comprising a taxane or a pharmaceutically acceptable salt thereof, polyvinylpyrrolidone, polysorbate, and sodium lauryl sulfate.
Dependencies are inferred from the claim text.