Hypromellose-graft-chitosan and methods thereof for sustained drug delivery
AssigneeThe University of Hong Kong
InventorsWing Fu Lai, Ho Cheung Shum
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Abstract
Described herein is a drug delivery system, which is based on a novel polymer namely hypromellose-graft-chitosan (HC), useful to deliver a drug to a patient in sustained and controlled release fashion. HC is highly water soluble across the pH range from 1.2 to 10, and has a high pH buffering capacity to provide a pH-stable environment for drug delivery. In addition, the drug delivery system provided herein exhibited a drug loading efficiency of over 90% in all drugs tested, which is 1-2 fold higher than the efficiency attainable by conventional chitosan, and achieved a 2-3 fold longer duration of sustained drug release.
Claims22
A drug delivery system for controlled and sustained delivery of an effective amount of a drug to a subject, comprising:
- a matrix comprising:
- (i) a hypromellose-graft-chitosan (HC);
- or (ii) a HC polyelectrolyte complex;
- and
- one or more drugs dispersed in the matrix.
A method of preparing a drug delivery system comprising the steps of:
- reacting chitosan with hypromellose to form a matrix comprising hypromellose-graft-chitosan (HC);
- and
- dispersing a drug in the matrix.
A polymer for drug delivery comprising a hypromellose-graft-chitosan (HC) wherein the HC is formed by reacting hypromellose with chitosan.
A polymer for drug delivery comprising a HC polyelectrolyte complex which is formed by reacting a HC with a polyelectrolyte.
Dependencies are inferred from the claim text.