Controlled release antimicrobial compositions and methods for the treatment of otic disorders
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Claims23
A method of treating an otic disease or condition in a pediatric patient, wherein the otic disease or condition is selected from acute otitis media with tympanostomy tubes or otitis media requiring tympanostonmy tube placement, the method comprising intratympanically administering to the pediatric patient a composition comprising poloxamer 407 and a therapeutically effective amount of multiparticulate ciprofloxacin, wherein the multiparticulate ciprofloxacin is non-microencapsulated, and wherein the composition provides a sustained release of ciprofloxacin in the ear for a period of at least 5 days after a single intratympanic administration.
A method of treating an otic disease or condition in a non-pediatric patient, wherein the otic disease or condition is selected from acute otitis media with tympanostomy tubes or middle ear effusion with otitis media undergoing tympanostomy tube placement, the method comprising intratympanically administering to the non-pediatric patient a composition comprising poloxamer 407 and a therapeutically effective amount of multiparticulate ciprofloxacin, wherein the multiparticulate ciprofloxacin is non-microencapsulated, and wherein the composition provides a sustained release of ciprofloxacin in the ear for a period of at least 5 days after a single intratympanic administration.
A method of treating an otic disease or condition in a patient older than 12 years of age, wherein the otic disease or condition is selected from acute otitis media with tympanostomy tubes or middle ear effusion with otitis media undergoing tympanostomy tube placement, the method comprising intratympanically administering to the patient a composition comprising poloxamer 407 and a therapeutically effective amount of multiparticulate ciprofloxacin, wherein the multiparticulate ciprofloxacin is non-microencapsulated, and wherein the composition provides a sustained release of ciprofloxacin in the ear for a period of at least 5 days after a single intratympanic administration.
Dependencies are inferred from the claim text.