Transdermal drug delivery system having multi-lamellar emulsion structure

A transdermal drug delivery system, which is a delivery system for transdermal absorption, having a multi-lamellar emulsion structure, comprising:

• lipids including a long-chain amide, a sterol, a fatty acid and a fatty alcohol;
• an emulsifier;
• an oil;
• and
• at least one active ingredient for transdermal administration,
• wherein a content of the lipids and the emulsifier is 5 to 30 wt %, a content of the active ingredient for transdermal administration is 0.001 to 25 wt %, and a sum of the long-chain amide and the sterol in the lipids is 0.1 to 10 wt %, based on the entire composition,
• wherein the multi-lamellar emulsion structure has a layered structure composed of a long periodicity phase and a short periodicity phase in a temperature range of 10° C. to 30° C., and
• wherein the long periodicity phase is 10 to 30 nm and the short periodicity phase is 3 to 6 nm.