Medical instruments and methods for fabricating same

A medical instrument fabricated by a method comprising thin film deposition, lithography, etching, polishing, cleaning, diffusion, ion implantation, direct writing, molecular self-assembly, laser ablation, packaging, assembly, or a combination thereof, wherein the size of the medical instrument ranges from 1 angstrom to 10 centimeters, and the method comprises chemical polishing, mechanical polishing, or chemical-mechanical polishing;

• wherein the medical instrument comprises:
• a blade;
• the blade comprises a thin elongated body, a top flat surface having an end point;
• a smoothly curved surface, extending from bottom of the thin elongated body toward the top flat surface and contacting the end point of the top flat surface, thereby forming an asymmetry, single-bevel cutting edge;
• and two opposite side surfaces, each extending between the top flat surface and the curved surface;
• wherein the blade comprises probing channels embedded in and running through the thin elongated body, and the probing channels are substantially parallel with the top flat surface and open through the curved surface.