Technologies for white matter hyperintensity quantification
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAdam M. Brickman, Jordan Muraskin, Frank A. Provenzano, Atul Narkhede
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Abstract
A method comprises selecting, via a computer, an intensity threshold value. The method also comprises defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value. The method further comprises extracting, via the computer, a plurality of voxels from the imaging data based on the defining. The method additionally comprises determining, via the computer, a total volume of the voxels based on the extracting. The method also comprises determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume.
Claims24
A method comprising:
- selecting, via a computer, an intensity threshold value;
- defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
- extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
- determining, via the computer, a total volume of the voxels based on the extracting;
- and
- determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume, wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.
A system comprising:
- a hardware processor;
- a memory operably coupled to the hardware processor, wherein the memory storing a set of instructions for execution via the hardware processor, wherein the set of instructions instructs the hardware processor to perform a method comprising:
- selecting an intensity threshold value;
- defining a plurality of hyperintensities on imaging data based on the intensity threshold value;
- extracting a plurality of voxels from the imaging data based on the defining;
- determining a total volume of the voxels based on the extracting;
- and
- determining a regional distribution of WMH based on an anatomical atlas and the total volume, wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.
A non-transitory computer-readable storage medium storing a set of instructions for execution via a processing circuit to implement a method comprising:
- selecting, via a computer, an intensity threshold value;
- defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
- extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
- determining, via the computer, a total volume of the voxels based on the extracting;
- and
- determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume, wherein the intensity threshold value is selected from a range of specificity-to-sensitivity intensity threshold values.
A method comprising:
- selecting, via a computer, an intensity threshold value;
- defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
- analyzing, via the computer, the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity;
- extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
- determining, via the computer, a total volume of the voxels based on the extracting;
- and
- determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume.
A system comprising:
- a hardware processor;
- a memory operably coupled to the hardware processor, wherein the memory storing a set of instructions for execution via the hardware processor, wherein the set of instructions instructs the hardware processor to perform a method comprising:
- selecting an intensity threshold value;
- defining a plurality of hyperintensities on imaging data based on the intensity threshold value;
- analyzing the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity;
- extracting a plurality of voxels from the imaging data based on the defining;
- determining a total volume of the voxels based on the extracting;
- and
- determining a regional distribution of WMH based on an anatomical atlas and the total volume.
A non-transitory computer-readable storage medium storing a set of instructions for execution via a processing circuit to implement a method comprising:
- selecting, via a computer, an intensity threshold value;
- defining, via the computer, a plurality of hyperintensities on imaging data based on the intensity threshold value;
- analyzing, via the computer, the imaging data for at least one of hyperintensity under-labeling or hyperintensity over-labeling based on at least one of a voxel location or a voxel light intensity;
- extracting, via the computer, a plurality of voxels from the imaging data based on the defining;
- determining, via the computer, a total volume of the voxels based on the extracting;
- and
- determining, via the computer, a regional distribution of WMH based on an anatomical atlas and the total volume.
Dependencies are inferred from the claim text.