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US 9,862,985 B2Granted
Identification and susceptibility of microorganisms by species and strain
AssigneeSpecific Technologies, LLC
InventorsSung Hyun Lim, Raymond Anthony Martino, Paul A. Rhodes
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Abstract
Devices, systems, and methods for strain-specific identification and assessment of susceptibility of microorganisms based on the response of sensors in a colorimetric sensor array to metabolic products of the microorganism.
Claims26
A method comprising:
- culturing a sample comprising a microorganism in a well containing growth media and an antibiotic, wherein a colorimetric sensor array is positioned proximate to the well, thereby exposing sensors in the colorimetric sensor array to volatile organic compounds produced by the microorganism in the presence of the antibiotic;
- and
- directly assessing the susceptibility of the microorganism to the antibiotic based on a response of the sensors in the colorimetric sensor array to the volatile organic compounds produced by the microorganism in the presence of the antibiotic.
A method comprising:
- culturing a test sample comprising a microorganism in a test well containing growth media and an antibiotic, wherein a test colorimetric sensor array is positioned proximate to the test well;
- culturing a control sample comprising the microorganism in a control well containing growth media, wherein a control colorimetric sensor array is positioned proximate to the control well;
- monitoring a color response of each sensor in the test colorimetric sensor array to organic compounds produced by the microorganism in the test well;
- monitoring a color response of each sensor in the control colorimetric sensor array to volatile compounds produced by the microorganism in the control well;
- and
- comparing the color response of each colorimetric sensor in the test colorimetric sensor array with the color response of each corresponding colorimetric sensor in the control colorimetric sensor array to assess the susceptibility of the microorganism to the antibiotic in the test well.
3 more elements
Dependencies are inferred from the claim text.