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US 9,862,934 B2Granted
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
AssigneeGenethon
InventorsOtto-Wilhelm Merten, Martin Marek, Monique Van Oers
Life of this patent
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Abstract
The present invention relates to methods for the production of biopharmaceuticals implementing a baculovirus-based system. These methods advantageously allow the production of biopharmaceuticals with a reduced number of or without contaminating baculoviral virions.
Claims8
A method for the production of a biopharmaceutical product, comprising:
- (a) infecting a biopharmaceutical-producing insect cell with at least one baculovirus, said at least one baculovirus comprising a genome coding for said biopharmaceutical product, and
- (b) maintaining the biopharmaceutical-producing insect cell under conditions such that the biopharmaceutical product is produced,
- wherein the genome of said at least one baculovirus is mutated to eliminate functional vp1054 gene product or wherein said biopharmaceutical-producing insect cell comprises an expression control system inactivating vp1054 gene expression.
Dependencies are inferred from the claim text.