Back to results
US 9,862,691 B2Granted
Cyclic triazo and diazo sodium channel blockers
AssigneeUniversity of Greenwich
InventorsMichael Leach, Laurence Harbige, Dieter Riddall, Karl Franzmann
Life of this patent
Estimating the term…
Abstract
A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): Each of A, N*, X, Y, R1, and R2 is defined herein. Also disclosed are compounds of the formula and a pharmaceutical composition containing such a compound.
Claims20
A method of treating a disorder comprising administering to a subject in need thereof a compound of general formula (I), or a salt, solvate or tautomer thereof,
- in which:
- X and Y are each N;
- A is selected from ditrifluoromethylphenyl, methoxyphenyl, ethoxyphenyl, dimethoxyphenyl, diethoxyphenyl, trimethoxyphenyl, triethoxyphenyl, fluoromethoxyphenyl, fluoroethoxyphenyl, difluoromethoxyphenyl, difluoroethoxyphenyl, trifluoromethoxyphenyl, trifluoroethoxyphenyl, and tetrafluoroethoxyphenyl;
- R1 is hydrogen or a substituent group selected from C1-10 alkyl, C2-10 alkenyl, C1-3 alkyl-aryl, C1-3 alkyl-heterocyclyl and C3-10 cycloalkyl, optionally substituted by hydroxy, halogen, carboxamido, halo C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy, or the Y nitrogen is unsubstituted;
- R2 is amino or a substituent group selected from C1-6 alkyl groups and phenyl groups, in which the substituent group is optionally substituted by hydroxy, halogen, halo-C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy;
- and
- N* is a group NRaRb where Ra and Rb are independently H or a C1-6 alkyl group;
- or
- N* is a piperazinyl ring optionally substituted by hydroxy, halogen, halo-C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy;
- wherein the disorder is selected from epilepsy, multiple sclerosis, neuropathic pain, and motor neurone disease.
7 more elements
A compound of general formula (I), or a salt, solvate or tautomer thereof,
- in which:
- X and Y are each N;
- A is selected from ditrifluoromethylphenyl, methoxyphenyl, ethoxyphenyl, dimethoxyphenyl, diethoxyphenyl, trimethoxyphenyl, triethoxyphenyl, fluoromethoxyphenyl, fluoroethoxyphenyl, difluoromethoxyphenyl, difluoroethoxyphenyl, trifluoromethoxyphenyl, trifluoroethoxyphenyl, and tetrafluoroethoxyphenyl;
- R1 is hydrogen or a substituent group selected from C1-10 alkyl, C2-10 alkenyl, C1-3 alkyl-aryl, C1-3 alkyl-heterocyclyl and C3-10 cycloalkyl, optionally substituted by hydroxy, halogen, carboxamido, halo C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy, or the Y nitrogen is unsubstituted;
- R2 is amino or a substituent group selected from C1-6 alkyl groups and phenyl groups, in which the substituent group is optionally substituted by hydroxy, halogen, halo-C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy;
- and
- N* is a group NRaRb where Ra and Rb are independently H or a C1-6 alkyl group;
- or
- N* is a piperazinyl ring optionally substituted by hydroxy, halogen, halo-C1-6 alkyl, C1-6 alkyl or C1-6 alkoxy.
6 more elements
Dependencies are inferred from the claim text.