Methods of treating hemoglobinopathies
AssigneeDuke University
InventorRahima Zennadi
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Abstract
Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from a β-arrestin1/2 inhibitor and/or a GRK2 inhibitor to the subject. Methods of inhibiting adhesion of sickle red blood cells to endothelial cells and adhesion to and activation of leukocytes are also provided.
Claims10
A method of alleviating at least one symptom of sickle cell disease in a subject comprising administering an inhibitor selected from a β-arrestin1/2 inhibitor comprising a small molecule inhibitor that acts directly on the β-arrestin1/2 protein and a GRK2 inhibitor comprising a small molecule inhibitor that acts directly on the GRK protein to the subject, wherein the at least one symptom is selected from vaso-occlusion, acute or chronic painful episodes, chronic hemolysis (aplastic crises), avascular necrosis, infection, end-organ damage, and erythroid hyperplasia.
A method of inhibiting adhesion of sickle red blood cells in a subject with sickle cell disease comprising administering an inhibitor selected from a β-arrestin1/2 inhibitor comprising a small molecule inhibitor that acts directly on the β-arrestin1/2 protein and a GRK2 inhibitor comprising a small molecule inhibitor that acts directly on the GRK protein to the subject to inhibit adhesion of the sickle red blood cells.
Dependencies are inferred from the claim text.