Organs for transplantation
OwnerSaverio LaFrancesca, Anthony P. Ting +1inventors
InventorsSaverio LaFrancesca, Anthony P. Ting, Robert J. Deans
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Abstract
The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.
Claims14
A method comprising transplanting an organ that has been exposed to exogenous stem cells, wherein the stem cells are non-embryonic, non-germ cells that express telomerase and can differentiate into cell types of at least two of endodermal, ectodermal, and mesodermal germ layers, wherein the stem cells have undergone at least 10-40 cell doublings in cell culture prior to their exposure to the organ, wherein the organ is exposed to the stem cells prior to transplantation into a recipient.
Dependencies are inferred from the claim text.