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US 9,857,381 B2Granted
Method for assaying sepsis in humans
AssigneeUniversitaet Zuerich
InventorsRolf Graf, Daniel Bimmler, Marius Keel
Life of this patent
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Abstract
The present invention relates to a reliable method of prediction of sepsis in humans after a trauma, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development of sepsis at early stages of the disease. Furthermore a method of determination of PSP/reg levels in serum is described.
Claims12
A method of quantifying pancreatic stone protein/regenerating protein (PSP/reg) in a serum sample comprising:
- (a) obtaining the serum sample from a human who suffered from trauma 3, 4 or 5 days after said trauma, wherein the human did not suffer from pancreatic injury, and
- (b) detecting an increased level of PSP/reg by measuring a level of PSP/reg that is higher than 60 ng/ml in said serum sample, wherein said measuring is performed by contacting the serum sample with an antibody against PSP/reg, and
- (c) treating said human having a level of PSP/reg higher than 60 ng/ml by administering an antibiotic to treat sepsis.
Dependencies are inferred from the claim text.