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US 9,856,459 B2Granted
Adsorptive membranes for trapping viruses
AssigneeWisconsin Alumni Research Foundation
InventorMark R. Etzel
Life of this patent
Estimating the term…
Abstract
A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. The ligand irreversibly and selectively binds viruses. The ligand also has a pKa sufficiently high to repel antibodies via electrostatic charge repulsion.
Claims12
A method of removing viruses from a solution suspected of containing viruses, the method comprising:
- contacting a solution suspected of containing viruses with a virus-trapping membrane, wherein the solution comprises a monoclonal antibody, wherein the virus-trapping membrane comprises a disposable, micro-porous filter membrane and a ligand immobilized on the membrane, wherein the ligand is tyrosinol.
Dependencies are inferred from the claim text.