Methods of administering inhibitory anti-factor XII/XIIA monoclonal antibodies

A method of treating venous, arterial, or capillary thrombus formation;

• thrombus formation in the heart;
• thromboembolism;
• thrombus formation during and/or after contacting blood with artificial surfaces;
• or intraluminal thrombi in a subject in need thereof, the method comprising administering to the subject an effective amount of an anti-Factor XII/XIIa monoclonal antibody or antigen-binding fragment thereof comprising an immunoglobulin heavy chain variable (vH) region and an immunoglobulin light chain variable (vL) region,
• wherein the vH region comprises:
• a heavy chain CDR1 consisting of the sequence of SEQ ID NO:
• 6;
• a heavy chain CDR2 consisting of the sequence of
• GIX1X2X3X4X5X6TVYADSVKG (SEQ ID NO:
• 8), wherein X1 is R, N, or D;
• X2 is P, V, I, or M;
• X3 is 5, P, or A;
• X4 is G, L, V, or T;
• X5 can be any amino acid;
• and X6 is T, G, or S;
• and
• a heavy chain CDR3 consisting of the sequence of
• ALPRSGYLX1X2X3X4YYYYALDV (SEQ ID NO:
• 10), wherein X1 is I, M, or V;
• X2 is S or K;
• X3 is P, K, T, or H;
• and X4 is H, N, G, or Q;
• and
• wherein the vL region comprises:
• a light chain CDR1 consisting of the sequence set forth in any one of SEQ ID NOs:
• 11 and 44-51;
• a light chain CDR2 consisting of the sequence of SEQ ID NO:
• 12;
• and
• a light chain CDR3 consisting of the sequence of AX1WX2X3X4X5RX6X7 (SEQ ID NO:
• 14), wherein X1 is A or S;
• X5 is L or V;
• X6 is G, L, or K;
• and X2, X3, X4 and X7 can be any amino acid.