Domain 5 of CD163 for use in antiviral compositions against PRRS, and transgenic animals
AssigneeThe University Court of the University of Edinburgh
InventorsTahar Ait-Ali, Simon Lillico, Alan Archibald, Christopher Bruce Alexander Whitelaw
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Abstract
The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD 163 in vivo.
Claims10
A genetically edited porcine animal comprising a genetic modification which alters the expression or activity of CD 163, wherein the genetic modification consists essentially of a deletion of exon 7 of the CD163 gene without replacing at least a portion of exon 7 of the CD163 gene.
A method of producing a genetically edited porcine animal comprising the steps of:
- providing a porcine animal cell;
- editing the genetic content of the cell to create a modification which alters the expression or activity of CD163, wherein the modification comprises consists essentially of a deletion of exon 7 of the CD163 gene without replacing at least a portion of exon 7 of the CD163 gene;
- and
- generating an animal from said cell.
Dependencies are inferred from the claim text.