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US 9,851,353 B2Granted
High sensitivity medical device and manufacturing thereof
AssigneeBanpil Photonics, Inc.
InventorAchyut Dutta
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Abstract
This invention relates to a system and methods including their manufacturing technologies for enhanced sensing capability of one or more bioagents covering from HIV, Pathogens, virus, to cells detection. More particularly, this invention is related to HIV and pathogen diagnosis system and methods which may increase its sensitivity and may reduce the diagnosis time. Furthermore, the diagnosis system and method may be applicable to all early stage patients with various age groups, where early and accuracy in diagnosis, are required.
Claims10
A sensing device comprising:
- a nanochip having a waveguide with a core and a cladding,
- said cladding having a periodic dielectric system that forms a photonic bandgap;
- a light source that sends optical signals through the core of said waveguide;
- a plurality of receptors for interacting with a specimen to be sensed, said receptors disposed in the periodic dielectric system of the cladding;
- a detector for converting optical signals sent through the core of the waveguide into electrical signals;
- at least one electrical processing circuit for processing electrical signals received from the detector, wherein said electrical processing circuit outputs a first signal and a second signal, wherein the first signal corresponds to the intensity of the optical signal passing through the waveguide without a specimen interaction with the receptors, and the second signal corresponds to the intensity of an optical signal passing through the waveguide with specimen interaction with the receptors;
- at least one monitoring system for determining concentration of a specimen based on signals received from the electrical processing circuit, wherein said monitoring system calculates a ratio of the first signal and the second signal, correlate said ratio to a change in effective refractive index of the cladding resulting from specimen interaction with the receptors, and correlate the change in effective refractive index to the concentration of the specimen;
- and
- at least one display unit.
6 more elements
A sensing device comprising:
- a removable section, wherein said removable section comprising:
- a nanochip having a first waveguide with a core and a cladding, said cladding having a periodic dielectric system that forms a photonic bandgap;
- an inlet for specimens;
- a microfluidic system for allowing specimen to move from said inlet to said nanochip;
- an outlet for specimens;
- and
- a plurality of receptors for interacting with a specimen to be sensed, said receptors disposed in the periodic dielectric system of the cladding;
- a main body, wherein said main body comprising:
- a substrate;
- a light source;
- a detector for converting optical signals into electrical signals;
- at least one electrical processing circuit for processing electrical signals received from the detector, wherein said electrical processing circuit outputs a first signal and a second signal, wherein the first signal corresponds to the intensity of the optical signal passing through the waveguide without a specimen interaction with the receptors, and the second signal corresponds to the intensity of an optical signal passing through the first waveguide with specimen interaction with the receptors;
- at least one monitoring system for determining the concentration of a specimen based on signals received from the electrical processing circuit, wherein said monitoring system calculates a ratio of the first signal and the second signal, correlate said ratio to a change in effective refractive index of the cladding resulting from specimen interaction with the receptors, and correlate the change in effective refractive index to the concentration of the specimen;
- at least one display unit;
- a second waveguide for guiding optical signals from said light source to said nanochip;
- and
- a third waveguide for guiding optical signals from said nanochip to said detector.
14 more elements
Dependencies are inferred from the claim text.