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US 9,850,538 B2Granted
Methods for diagnosing and treating diabetes
AssigneeThe Board of Trustees of the University of Illinois
InventorSundararajan Jayaraman
Life of this patent
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Abstract
Methods and kits for diagnosing and treating type I diabetes based upon the expression of macrophage-specific Chymotrypsin-Like Elastase Family, Member 3B, either alone or in combination with sialic acid-binding immunoglobulin-like lectin-1, are provided.
Claims6
A method for diagnosing a subject with type diabetes comprising
- (a) obtaining a sample from the subject;
- (b) measuring the expression of Chymotrypsin-Like Elastase Family, Member 3B (CELA3B) and optionally sialic acid-binding immunoglobulin-like lectin-1 (SIGLEC-1) in the sample, wherein the expression of CELA3B is measured using oligonucleotides consisting of SEQ ID NO:
- 1 and SEQ ID NO:
- 2;
- (c) comparing the expression of CELA3B and optionally SIGLEC-1 in the sample to the expression of CELA3B and optionally SIGLEC-1 in a control;
- and
- (d) diagnosing the subject with type I diabetes when the expression of CELA3B and optionally SIGLEC-1 in the sample from the subject is elevated compared to the expression of CELA3B and optionally SIGLEC-1 in the control.
4 more elements
A method for treating a subject diagnosed with type I diabetes comprising
- (a) obtaining a sample from the subject;
- (b) measuring the expression of Chymotrypsin-Like Elastase Family, Member 3B (CELA3B) and optionally sialic acid-binding immunoglobulin-like lectin-1 (SIGLEC-1) in the sample, wherein the expression of CELA3B is measured using oligonucleotides consisting of SEQ ID NO:
- 1 and SEQ ID NO:
- 2;
- (c) comparing the expression of CELA3B and optionally SIGLEC-1 in the sample to the expression of CELA3B and optionally SIGLEC-1 in a control;
- and
- (d) treating the subject for diabetes when the expression of CELA3B and optionally SIGLEC-1 in the sample from the subject is elevated compared to the expression of CELA3B and optionally SIGLEC-1 in the control.
4 more elements
A kit comprising oligonucleotides consisting of SEQ ID NO:1 and SEQ ID NO:2.
Dependencies are inferred from the claim text.