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US 9,850,472 B2Granted
P97-antibody conjugates and methods of use
AssigneeBioasis Technologies, Inc.
InventorsTimothy Z. Vitalis, Reinhard Gabathuler
Life of this patent
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Abstract
The present invention provides p97-antibody conjugates and related compositions and methods, which may be used in any of a variety of therapeutic methods, including methods for the treatment of cancers such as Her2/neu-expressing and Her1/EGFR-expressing cancers.
Claims14
A conjugate comprising a p97 polypeptide covalently or operatively linked to an antibody or antigen-binding fragment thereof that specifically binds human Her1/EGFR (epidermal growth factor receptor), wherein the p97 polypeptide is a soluble p97 polypeptide that consists of residues 20-711 of SEQ ID NO:
- 1 or differs from residues 20-711 of SEQ ID NO:
- 1 by substitution, deletion, addition, and/or insertion of five amino acids or fewer, and wherein the p97 polypeptide is effective for transporting the anti-Her1/EGFR antibody or antigen-binding fragment thereof across the blood brain barrier.
Dependencies are inferred from the claim text.